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NIH		NIGMS			Budget Code:
National Institute of General Medical Sciences Project Through its extramural grants program, NIGMS is supporting activities that contribute significantly to understanding the theoretical basis of the structure and dynamics of biological macromolecules, including proteins and nucleic acids. This program supports the prediction of the folded structure of proteins from the amino acid sequence, solvation of proteins and nucleic acids, new computational methods for solving the phase problem in crystallography, and the binding of ligands to proteins, the latter with an emphasis on targeted drug design. These efforts are done in collaboration with investigators at and make extensive use of facilities supported by the HPCC initiatives at the National Science Foundation, the National center for Research Resources, and the Division of Computer Research and Technology.							Budget ($ M) FY 95 Act   FY 96 Pres   FY 96 Est   FY 97 Rqst 0.50 Program Component Areas   FY 96 FY 97 HECC   0.50 LSN     HCS     HuCS     ETHR     Agency Ties DARPA   NSF Partner DOE   NASA   NIH   NSA   NIST   NOAA   EPA   ED   AHCPR   VA
Milestone Changes
FY 1995 Actual Milestones			FY 1996 Estimated Milestones	FY 1997 Agency Requested Milestones
				Continued progress in the areas supported by NIGMS with an emphasis on capitalizing on recent improvements in protein folding algorithms, and searching algorithms for finding ligands capable of binding to macromolecular targets. Making software that results from these efforts available through the HPCC initiatives supported by NSF, NCRR, and DCRT.